Hepatotoxicity of Ipomoea Batatas Leaf Extract on Male Wistar Rats
I.A Ekpo, R.B Agbor, U.B Ekaluo, E.V Ikpeme, S.E. Kalu, J.E Osang
American International Journal of Biology, 1(1), pp. 21-28.

Abstract
The hepatotoxic potential of Ipomoea batataleaf extract on the liver tissues as well as thecharacteristics of the liver pathology on maturemale wistar rats was determined. Mature leavesof I. batata were obtained and air dried for twodays after which there were subjected to ovendrying at 200C for two minutes and thenpulverized using an electric blender. Maturewistar rats of twelve weeks old weighingbetween 154-170g were fed with varying dosesof feed/ extract mixture viz: 0g/0.643kg (Group1) as control, 6g/0.648kg (Group 2), 8g/0.666kg(Group 3) and 10g/0.678kg (Group 4) for twoweeks. After the treatment, the animals weresacrificed and the liver excised and weighed.Sectioning and slide preparation of the liver andhistological examination of the liver werecarried out using the light microscope.Thereafter, a photomicrograph of the slideswere taken. The result shows that there was asignificant increase (p<0.05) in the meanweight of the liver in the four groups of albinorats while the photomicrograph showsvariations in the normal cyto-architecture of theliver in the various groups. These variationssuggest that there is hepatocellular injuryresulting from the extract fed the rats. The leafextract therefore, is hepatotoxic at the doses fedthe animals.

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Ekop et al. (2013). Hepatotoxicity of Ipomoea Batatas Leaf Extract on Male Wistar Rats. American International Journal of Biology, 1(1), 21-28.

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I.A Ekpo , Department of Genetics and Biotechnology, University of Calabar, P.M.B 1115, Calabar, Cross River State, Nigeria.

R.B Agbor, Department of Genetics and Biotechnology, University of Calabar, P.M.B 1115, Calabar, Cross River State, Nigeria.

U.B Ekaluo, Department of Genetics and Biotechnology, University of Calabar, P.M.B 1115, Calabar, Cross River State, Nigeria.

E.V Ikpeme , Department of Genetics and Biotechnology, University of Calabar, P.M.B 1115, Calabar, Cross River State, Nigeria.

S.E. Kalu, Department of Genetics and Biotechnology, University of Calabar, P.M.B 1115, Calabar, Cross River State, Nigeria.

J.E Osang , Department of Genetics and Biotechnology, University of Calabar, P.M.B 1115, Calabar, Cross River State, Nigeria.